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Jhamtani, Reena C.

Emergence of Zebrafish as a Biomarker for Pesticide Poisoning in Forensic Toxicology Research

Abstract Views :252 | PDF Views:0

Authors

Saurabh Shukla ¹, Reena C. Jhamtani ¹, Rakhi Agarwal ¹

Affiliations
1 Laboratory of Analytical and Molecular Toxicology (Forensic Chemistry and Toxicology Laboratory), Institute of Forensic Science, Gujarat Forensic Sciences University, Sector 09, Gandhinagar – 382007, Gujarat, IN

Source

Toxicology International (Formerly Indian Journal of Toxicology), Vol 25, No 1 (2018), Pagination: 68-77

Abstract

Forensic toxicology is the branch of forensic science which utilizes toxicology, pharmacology and analytical chemistry to help in legal investigations of suicidal, homicidal and accidental poisoning cases. Accidental poisoning cases related to occupational exposure of pesticides are also very common. Zebrafish is a versatile model organism that has been used as a model organism in different field of science, has various practical advantages over other vertebrate models. Present review summarizes the effects of pesticides and the use of adult zebrafish as a model organism in forensic toxicology research to understand the symptoms/effects and mechanism of pesticide poisoning.

Keywords

Forensic Science, Forensic Toxicology, Oxidative Stress, Pesticide Poisoning, Zebrafish.

Full Text

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Chemical Components in Smokeless Tobacco Products and Impact on Health

Abstract Views :98 | PDF Views:0

Authors

Shilpa Gupta ¹, Nilesh J. Jain ¹, Reena C. Jhamtani ¹

Affiliations
1 Harm Reduction Research and Innovation Centre [HRRIC], Virtualis Services Pvt Ltd., Mumbai – 400013, Maharashtra, IN

Source

Toxicology International (Formerly Indian Journal of Toxicology), Vol 28, No 4 (2021), Pagination: 279-309

Abstract

Smokeless Tobacco [SLT], a non-combustible form of tobacco, is consumed by 350 million people in 133 countries across the globe. Worldwide, Smokeless Tobacco products vary greatly in their formulations and chemical composition. Understanding of toxic and carcinogenic constituent variations in such products can provide valuable insights for the development of effective tobacco control policies. Though the assessment of SLT products has been done earlier, the information is not available in an inclusive and handy format as entire profiling. Hence, there is a vital need to develop a one-stop information source providing comprehensive information on SLT products. PubMed and Google scholar databases were systematically searched from 1995 till April 2020 for observational studies on Smokeless Tobacco products and their chemical components. The included studies were evaluated and data were extracted and reviewed.A wide variation was noted in the association of various diseases and specific Smokeless Tobacco product constituents based on their nature and inherent toxicity. The majority of chewing tobacco products displayed a higher risk for users.This review emphasizes the significant positive association of Smokeless Tobacco product components with health hazards. Pathways estimates for smokeless tobacco-associated disease need further analysis. The profiling of Smokeless Tobacco products also requires multi-centric well-designed studies. Further, the information would be a guide for researchers interested in the components of SLT products.

Keywords

Biological Mechanism, Disease Pathway, Hazard, Profiling, Smokeless Tobacco, Tobacco Constituents

Full Text

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